Publications and Patents



“Comparison of Alicyclobacillus acidocaldarius o‑Succinylbenzoate Synthase to Its Promiscuous N‑Succinylamino Acid Racemase/o‑Succinylbenzoate Synthase Relatives” Denis Odokonyero, Andrew W. McMillan, Udupi A. Ramagopal, Rafael Toro, Dat P. Truong, Mingzhao Zhu, Mariana S. Lopez, Belema Somiari, Meghann Herman, Asma Aziz, Jeffrey B. Bonanno, Kenneth G. Hull, Stephen K. Burley, Daniel Romo, Steven C. Almo, and Margaret E. Glasner Biochemistry 2018, 57(26), 3676-3689. Link:

“Triterpenoids from the stem bark of Vitellaria paradoxa (Sapotaceae) and derived esters exhibit cytotoxicity against a breast cancer cell line” Kenneth O. Eyong, Guerisson Baïrys, Anna A. Eno, Joseph Taube, Kenneth G. Hull, Gabriel N. Folefoc, Harquin S. Foyet, and Daniel Romo Med. Chem. Res. 2018, 27, 268-277.  Link:


“Bioactive Seco-Lanostane-Type Triterpenoids from the Root of Leplaea mayombensis” Lazare S. Sidjui,  Kenneth O. Eyong, Kenneth G. Hull, Gabriel N. Folefoc, Valerie M. Leddet, Gaёtan Herbette, Evelyne Ollivier, Joseph Taube, Kevin Klausmeyer, and Daniel Romo J. Nat. Prod. 201780, 2644-2651. Link:

“A Strategy for Dual Inhibition of the Proteasome and Fatty Acid Synthase with Belactosin C-Orlistat Hybrids” Mingzhao Zhu, Wayne D. Harshbarger, Omar Robles, Joanna Krysiak, Kenneth G. Hull, Sung Wook Cho, Robyn D. Richardson, Yanyan Yang, Andres Garcia, Lindsey Spiegelman, Bianca Ramirez, Christopher T. Wilson, Ju Anne Yau, James T. Moore, Caitlen B. Walker, James C. Sacchettini, Wenshe R. Liu, Stephan A. Sieber, Jeffrey W. Smith and Daniel Romo Bioorg. Med. Chem. 201725, 2901-2916.    Link:



“HSV-2 Virion Host Shutoff Endoribonuclease Activity is Required to Disrupt Stress Granule Formation” Renee Finnen, Mingzhao Zhu, Jing Li, Daniel Romo, and Bruce Banfield J. Virol.2016, 90, 7943-7955. Link: 10.1128/jvi.00947-16

“Chemical Mechanism of the Phosphotriesterase from Sphingobium sp. Strain TCM1, an Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants” Andrew N. Bigley, Dao Feng Xiang, Zhongjie Ren, Haoran Xue, Kenneth G. Hull, Daniel Romo, Frank M. Raushel J. Am. Chem. Soc. 2016, 138, 2921-4.  Link



“Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-induced Platelet Reactivity Independent of Reactive Oxygen Species” Hengjie Yuan; Katie Houck; Ye Tian; Uddalak Bharadwaj; Ken Hull; Zhou Zhou; Mingzhao Zhu; Xiaoping Wu; David Tweardy; Daniel Romo; Xiaoyun Fu; Yanjun Zhang; Jianning Zhang; Jing-fei Dong PLOS ONE 2015 10(12): December 8, 2015 DOI: 10.1371/journal.pone.0146626. Link



“Interrogation of the Substrate Profile and Catalytic Properties of the Phosphotriesterase from Sphingobium sp. Strain TCM1: An Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants and Plasticizers” Dao Feng Xiang, Andrew N. Bigley, Zhongjie Ren, Haoran Xue, Kenneth G. Hull, Daniel Romo, Frank M. Raushel Biochemistry 2015, 54, 7539–7549. Link



“Role of an Active Site Loop in the Promiscuous Activities of Amycolatopsis sp. T-1-60 NSAR/OSBS” Andrew W. McMillan, Mariana S. Lopez, Mingzhao Zhu, Benjamin C. Morse, In-cheol Yeo, Jaleesia Amos, Ken Hull, Daniel Romo, Margaret E. Glasner Biochemistry 2014, 53, 4434-4444. Link


“Promiscuity of Exiguobacterium sp. AT1b o-Succinylbenzoate Synthase Illustrates Evolutionary Transitions in the OSBS Family” Ashley M. Brizendine, Denis Odokonyero, Andrew W. McMillan, Mingzhao Zhu, Ken Hull, Daniel Romo and Margaret E. Glasner Biochem. Biophys. Res. Commun. 2014,450, 679-684. Link


“Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents” Woon-Kai Low, Jing Li, Mingzhao Zhu, Sai Shilpa Kommaraju, Janki Shah-Mittal, Ken Hull, Jun O. Liu, Daniel Romo Bioorg. Med. Chem. 2014, 22, 116-125. Link



“Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification” Pingzhu Zhou, Yijing Zhang, Qing Ma, Fei Gu, Daniel S. Day, Aibin He, Bin Zhou, Jing Li, Sean Stevens, Daniel Romo, Peter J. Park, and William T. Pu Proc. Natl. Acad. Sci., 2013, 110, 15395-15400. Link



“Simultaneous Arming and Structure-Activity Relationship Studies of Natural Products via C- and N-Amination: Cellular Targets of Eupalmerin Acetate” Jing Li, Justin S. Cisar, Congying Zhou, Brunilda Vera, Howard Williams, Abimael D. Rodríguez, Benjamin F. Cravatt, Daniel Romo Nat. Chem. 2012, 5, 510-517. Link




“A Chemifluorescent Immunoassay for the Determination of Marinobufagenin in Body Fluids”, Abi-Ghanem, D.; Lai, X.Z.; Berghman, L.C.; Horvat, D.; Li, J.; Romo, D.; Uddin, M.N.; Kamano, Y.; Nogawa, T.; Xu, J.P.; Pettit, G.R.; Puschett, J.B. J. Immunoassay Immunochem. 2011, 32, 31-46. Link


“Marinobufagenin Levels in Preeclamptic Patients: A Preliminary Report” Enoch Agunanne, Darijana Horvat, Recherael Harrison, M. Nasir Uddin, Richard Jones, Thomas J. Kuehl, Daad Abi Ghanem, Luc R. Berghman, Xinzhong Lai, Jing LiDaniel Romo, Jules B. Puschett  American Journal of Perinatology 2011, 28, 509-514. Link


“Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite differentiation, roliferation, and viability” Yau W-K.; Blisnick, T.; Taly J.-F.; Helmer-Citterich, M.; Schiene-Fischer, C.; Leclercq, O.; Li, J.; Schmidt-Arras, D.; Morales, M. A.; Notredame, C.; Romo, D.; Bastin, P.; Späth, G. F. PLoS Negl. Trop. Dis. 2010, 4, e729. Link


Pateamine A Derivatives: Translation Inhibitors

Daniel Romo, Omar Robles, Mingzhao Zhu, Kenneth G. Hull “Beta-amino Pateamine A Derivatives for Treating Chronic Lymphocytic Leukemia” PCT Int. Appl. October 5, 2017 WO 2017173313 A1.

Daniel Romo, Omar Robles, Mingzhao Zhu, Kenneth G. Hull “Alpha-amino Pateamine A Derivatives for Treating Chronic Lymphocytic Leukemia” PCT Int. Appl. October 6, 2016 WO 2016161168 A1.

Daniel Romo, Nam Song Choi “Potent Immunosuppressive, Derivatives and Uses” September 2014 Patent # US8841285 B2

Daniel Romo, Nam Song Choi “Potent, Simplified Derivatives of Pateamine A” June 2007 Patent # US7230021; Also issued in Switzerland, France, Germany and the United Kingdom April 2012

Nam Song Choi, Jun O Liu, Woon-Kai Low, Zonggao Shi, Yongjun Dang, Tilman Schneider-Poetsch, Daniel Romo “Anticancer agents and use” Patent # US7737134 June 2010

Belactosin-Orlistat Hybrids as Dual Inhibitors of the Proteasome/FAS

Daniel Romo, Sung Wook Cho “Novel Belactosin Derivatives as Therapeutic Agents/Biological Probes and Their Synthesis” February 2012 Patent # US11/775154

Determination of Marinobufagenin: Assay Development

Jules B. Puschett, Daniel Romo, Luc R. Berghman, Daad Ali Abi-Ghanem, Xinzhong Lai, Method for Determination of Marinobufagenin Levels and Compounds Employable in Such Method U.S. Patent Issued August  2011 Patent # US 2011/0207154 A1.