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The Baylor CPRIT Synthesis and Drug-Lead Discovery Laboratory will focus on the devolpment and application of chemo- and site-selective methods for the derivatization of biologically and pharmacologically important natural products and other bioactive small molecules and the high throughput optimization of synthetic transformations.

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Lab News:

New Manuscripts Accepted for Publication:

“Creating novel translation inhibitors to target pro-survival proteins in chronic lymphocytic leukemia” Rong Chen, Mingzhao Zhu, Rajan R Chaudhari, Omar Robles, Yuling Chen, Wesley Skillern, Qun Qin, William Wierda, Shuxing Zhang, Kenneth G. Hull, Daniel Romo, William Plunkett Leukemia 30 January 2019 link

“A Novel Actin Binding Drug with In Vivo Efficacy” Akshaya Ravichandran, Mengxin Geng, Kenneth G. Hull, Jing Li, Daniel Romo, Shi-En Lu, Aaron Albee, Christopher Nutter, Donna M. Gordon, Mahmoud A. Ghannoum, Steve W. Lockless, Leif Smith Antimicrobial Agents and Chemotherapy 2019 link